Keloids
A study was conducted to determine whether Keloid history affected reoccurrence. This was an eventual longitudinal study to determine whether histopathological parameters of keloid influence recurrence.
Keloids are fibro proliferative disorders characterized by high recurrence rates, with few factors known to influence the same. Patients with keloids managed by surgical excision were followed up at Kenyatta National Hospital between August 2018 and July 2020.
A total of 90 patients with 104 keloids were recruited in the study. The excised keloids were processed for histology using haematoxylin, /eosin, Masson, and trichrome stains. The slides were analysed for inflammatory cells, fibroblasts, and capillary density using the hot spot technique and correlated to keloid recurrence.
Overall keloid recurrence rate was 28.6%. There was no correlation between mast cells and vascularity status with recurrence. Routine histology should, therefore, be performed to determine these parameters.
Close monitoring and second-line therapy should be considered for patients with elevated macrophages and/or lymphocytes so as to reduce the risk of recurrence.
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